What is the best way to improve immune system to avoid flu and Corona virus?

Who is most risky people for corona virus?

• People of all ages can be infected by the new coronavirus, but older people, and people with pre-existing medical conditions (such as asthma, diabetes, heart disease) appear to be more vulnerable to becoming severely ill with the virus and tend to have less active gut microbiomes.

Is there any treatment for a novel coronavirus?

• World Health Organization(WHO) clearly says that there is not specific medical treatment for disease caused by a novel coronavirus.

What do all the authorities recommend the first sanitary protective measure against a novel coronavirus should be?

• Washing your hands 10 times a day with soap and water or using alcohol-based hand rub kills viruses that may be on your hands. And maintain social distance to stay away from droplets spread virus… That is quite important to stay away from the virus but everyone is now practicing those!!!

Who is most vulnerable to coronavirus?

• It is found with coronavirus that people of all ages with weakened immune systems or certain diseases also face higher risks and are experiencing the coronavirus pandemic with particular anxieties.https://www.statnews.com/2020/03/16/lower-coronavirus-death-rate-estimates/ 

What is the most important base steps to start to enhance immune system?

• Any excising daily even for 30 minutes mobilizes white cells or immune cells to fight against any virus invading the body. Help to lower stressful feeling. Just moving around is better than nothing.
• A good sleep strengthen your immune response to detect and destroy germs and virus.
• Drinking alcohol lots is weaken the first line soldiers of macrophages and lymphocytes.
• Eat well with a few kinds of fruits and vegetables , better not to have too much cakes and sweets
• Taking vitamin C, D, Zinc to enhance natural defense mechanism.
• Taking quality phytochemicals to combat virus by stimulating lymphocytes. 

Coronavirus induces a leaky gut syndrome?

• Yes, coronavirus causes the inflammation of the intestinal linings. The broken membranes of the intestine allow bacteria and toxins to enter the bloodstream and lower the while cell activity.

https://pubs.acs.org/doi/full/10.1021/acs.jafc.6b02776 

Why are blackcurrant anthocyanins so effective as immune system booster?

• BCA has been studied by many research labs and universities for 15 years and it has been proven effective as one of the highest immune booster in relation toperipheral circulation disorder, increasing the blood flow,  asthma on human testing, neutrophils secretion , influenza human testing , etc .

https://www.nzblackcurrants.com/assets/pdfs/Health-Benefits-Review-updated-19-December-2017.pdf

https://drive.google.com/file/d/1m6e0F8Xue05vgO3-MAT9kRCMwdRp9YrM/view

 Do Blackcurrant anthocyanins support to fix leaky gut syndrome?

• Blackcurrant anthocyanins(BCA) exhibited therapeutic potential for inflammatory bowel diseases
• BCA kills bad bacteria and reduce G glucuronase enzyme which may cause colon cancer and Crohn’s disease.
• Under swamps of mucus and microbes, our bodies are protected by epithelial cells which are really hard to get through. They make antiviral compounds that are quite hostile against coronavirus.”
• Anthocyanins and probiotics inhibit colitis and improve intestinal barrier function by a number of interconnected mechanisms. These bioactive components modulate oxidative stress and inflammation directly in intestinal epithelial cells, but also modulate gut microbiota, affect activation of immune cells, and modulate cytokine activity.

https://www.researchgate.net/publication/225338571_The_ability_of_blackcurrant_extracts_to_positively_modulate_key_markers_of_gastrointestinal_function_in_rats

 How do blackcurrant anthocyanins support to block from influenza virus?

• Multiple studies show that blackcurrant anthocyanins taken orally can boost the mucosal defense warding off the harmful viruses that cause upper respiratory tract infections like colds, asthma and flu.

https://www.jstage.jst.go.jp/article/fms/59/1/59_35/_pdf

https://www.ncbi.nlm.nih.gov/pubmed/11885927

http://www.jtbpd.com/information.php?information_id=64&xcSID=3qs6rqemlmda147elonrhl31r4

https://mro.massey.ac.nz/bitstream/handle/10179/1212/02whole.pdf?sequence=1&isAllowed=y 

How much anthocyanin should be taken to enhance immune system of the first fighters of neutrophils and macrophage?

• It is suggested to take 1.6mg/kg to enhance the production of the first fight of while cells, neutrophils which means about 100mg of anthocyanins per one time for 60kg weighted person.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548855/

https://www.karger.com/Article/FullText/487202

Does blackcurrant anthocyanins support to function of neutrophils, macrophage and lymphocytes to combat coronavirus? 

•  Blackcurrant anthocyanins works as anti-inflammatory, anti-carcinogenic, and antibacterial. It has its antiviral properties by blocking the inflammatory pathway called the NFkB pathway.

https://www.ncbi.nlm.nih.gov/pubmed/17634269

https://www.ncbi.nlm.nih.gov/pubmed/24565673

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548855/

Does blackcurrant anthocyanins support to modulate the inflammatory effect caused by macrophage M1 activated by lipopolysaccharides?

• Blackcurrant anthocyanins support to the first virus fighter, macrophage , to exert anti-inflammatory effects in the activation of macrophages to fight against coronal virus.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566326/

Why have JTB blackcurrant anthocyanins been made into throat lozenges and flu protecting supplements in the last more than 15 years?

• According to studies of Fukushima Medical University and Asahikawa Medical University, anthocyanins Rich blackcurrant extract can inactivate more than 98% of the influenza A and B viruses that out-break prevalently every year. IN the USA the flu killed approximately 60,000 peoples and 45 million peoples infected in the year of 2018 and the US flu of the year 2019 killed more than 34,000 peoples and 34million peoples are infected.
• Before a virus can penetrate a host cell, attachment is achieved when specific proteins on the viral envelope bind to specific receptor proteins on the cell membrane of the target cell.
• This process is called “adsorption,” and according to Professors of Fukushima Medical University and Asahikawa Medical University, blackcurrant anthocyanins has a proactive component that covers the surface of the virus or virus receptor, which mechanism is thought to inhibit virus “adsorption”.
• Repeated experiments were performed by those medical Universities on a variety of flu viruses with blackcurrant anthocyanins and those anthocyanins compositions are remarkably inhibiting more than 98% of “adsorption”, particularly for influenza A and B viruses. Although there is a difference between strong and weak in yearly altered virus RNA , similar effects have been confirmed for other viruses, and the inhibition of “adsorption”can be expected to be effective against a new type of influenza, a kind of new coronavirus that is already hurting the world economy as well as the social safety of the world.

https://pubmed.ncbi.nlm.nih.gov/12601672/

https://pubmed.ncbi.nlm.nih.gov/23842512/

High quantity and quality of the anthocyanins contained in Vision Smart Supreme is a most reliable fighter against a novel coronavirus!

• Vision Smart Supreme has been patronized by thousands of consumers not only for maintaining specific eye healthbut also for supporting to improve immune systemto help to avoid “adsorption” of every yearly occurring virus in our body cells. With  210mg of high pure and quality anthocyanins per day,  Vision Smart Supreme is ranked on the top notch nutraceutical among all other same kinds of the supplements currently marketed in the world.

Blackcurrant Anthocyanins (Vision Smart Supreme) help to inhibit virus attachment to cells and reduce cytokine storm?

1.Covid-19 and Virus Invasion and Cytokine Storm

 What are ACE2 of human host cell and S-Protein of COVID-19?

How new corona virus attaches to the receptor of our host cell called angiotensin-converting enzyme 2(ACE2) of which system is also a key player of treatment of hypertension.

The tiny key molecular key (spike protein) of Covid-19 that facilitates the virus entry into the host cells and rapidly replicate the viruses into lung, kidney, gastrointestinal tract, vascular endothelial streams throughACE2.

What is the most dreadful symptom to make infected people fall into serious pneumonia?      

 IT IS CYTOKINE STORM causing Sudden Crash in Patients withCOVID-19!!

TENS OF MILLIONS OF PEOPLE were killed by CYTOKINE STORMduring the pandemic of Spanish flu.

Cytokine Stormis now seen as a likely major cause of mortality in the 1918-20 “Spanish flu”–which killed more than 50 million people worldwide and the H1N1 “swine flu” in 2009and H5N1 “bird flu” of recent years—and now COVID-19.

What Cytokines are causing infected people of Covid-19 with serious lung disease?

When theCytokinesthat raise immune activity become too much abundant, the immune system is not able to stop itself. Those immune cells spread beyond infected body parts mainly from lungs and start attacking healthy tissues, gobbling up red and white blood cells and damaging the lung and liver. The blood vessels get so leaky that the lungs may fill with fluid and fall into acute respiratory distress.

Apart from a surge in main Cytokine of interleukin-6,the body may also show high swirling levels of other Cytokines,Chemokines and Serine ProteasecalledTNF, IFN-ab, IL-1, and Mcp1/CCL2. neutrophil- and monocyte-associated MMP-9, neutrophil elastase.

Dr. Randy Cron, a professor at the University of Alabama at Birmingham, says at the New York Times that “Cytokine Stormhappens when the pro-inflammatory cytokinesget out of control in abundance. Instead of helping to fight virus and bacteria, it gets overly activated and that these affluent pro-inflammatory cytokinesis what leads to multi-organ failureand potentially death,

2.BLACKCURRANT ANTHOCYANINS against VIRUS ADSORPTION and CYTOKINE STORM

Nearly 300,000 patients died in H1N1 Pandemic Influenza 2009!! 

Cytokine Stormis now understood as a major cause of mortality in the 1918-20 “Spanish flu”–which killed more than 50 million peopleworldwide and the H1N1 “swine flu” and H5N1 “bird flu” of recent years—and nowCOVID-19.

 The pandemic H1N1influenza of the year 2009 suddenly occurred spreading into North America, South America, Africa, European countries, Southeast Asia, Japan and widely infected more than 200 countries around the world.

British Medical Journal LANCETannounced that the US Center for Disease Control (CDC)estimated the death toll to be approximately more than 280,000worldwide.

Blackcurrant Anthocyanins significantly inhibited H1N1 Virus attached to Human Cell!!  

 In 2002, Asahikawa Medical Universityannounced that it had a remarkable inhibitory effect by 98% on the adsorption of influenza A and Bon human cells by Anthocyanins/phenolic of blackcurrant.

Four species of influenza were blocked to enter into human cells by blackcurrant anthocyanins!!

In the year 2013, a joint research team led by Professor Suzutani of Fukushima Medical Universityand Asahikawa Medical Universityhad disclosed studies done  on the inhibition of virus adsorption that  Kurokarin (blackcurrant)had a remarkable inhibitory effect of 98% inhibitionon the adsorption of pandemic influenza A (H1N1) 2009, Hong Kong influenza (IFV-AH3), Russian influenza (IFV_AH1),

 Blackcurrant Anthocyanins are effectively inhibited Herpes and Adenovirus infection!!

In addition, blackcurrant anthocyanins inhibited on the cell membrane the herpes bacillus (HSV-1)and pharyngitis infecting the mouth, throat and eye area causing swelling, throat pain and high fever with high fever and throat pain.

Many studies show that Blackcurrant anthocyanins and polyphenols suppress the replication of adenovirus infectious bacteria (AdV = pool fever) that causes conjunctivitis that causes irritation of the eye, tonsillitis, eye congestion, eyes, etc.

Cytokines and Serine Proteinases causing inflammation are significantly reduced!!

Studies done at Pennsylvania University showed that the blackcurrant extract inhibited all serine proteinasestested. MMP-1 and MMP-9,inflammatory compounds of Cytokine Storm, were significantly inhibited by pure anthocyanins during 4 hours incubation test. Serine proteinases related periodontal diseasewere also significantly inhibited by pure anthocyanins.

Most Effective Adaptive Immune Response by Blackcurrant Anthocyanins

Numerous studies shows that blackcurrant anthocyanins(BA) dampen inflammation through multiple pathways. Directly or indirectly the four compositions of blackcurrant anthocyanins and polyphenols suppress the activity of nuclear transcription factors, such as NFκB, and reduce the production of pro-inflammatory enzymes and cytokines, including COX2, tumor necrosis factor (TNF)-α, and interleukin (IL)-4, 6, 8 with serine proteases while anti-inflammatory cytokines IL10 , IL13 secreted by BA support to counterbalance the adaptive immune cells in inflammatory diseases.

Pre-Clinical Data (2015 Edition by JTB):  

Lab Tests Show Anthocyanins in Vision Smart Supreme Have Powerful Anti-Virus & Microbial Properties, Ideal For Virus Prevention!

Researchers showed the exact same Blackcurrant Anthocyanins extract found in Vision Smart Supreme had incredibly powerful anti-viral and anti-bacterial effects. This led researchers to state, “The findings demonstrate the potential of blackcurrant extract as a functional food for cold and flu care”!

Test Materials: Human cells in culture

Results: Blackcurrant Anthocyanins inhibited infection of cells by H1N1 2009, HSV-1 virus by

over 95%. Plus, killed over 99% of certain bacteria’s.

Institution: Fukushima Medical University School, Asahikawa Medical University, Japan.

Publican: Ikuta, K. et al (2012)

Clinical #2 (2015 Edition by JTB):

Vision Smart Supreme’s Blackcurrant Anthocyanins Help Protect and Against Influenza via Powerful Anti-inflammatory Properties!!

Norwegian researchers found Blackcurrant reduced the amounts of inflammatory compounds in the blood. These exciting results suggest Vision Smart Supreme (with the highest available does of blackcurrant anthocyanins) may be useful in protecting against Influenza.

Participants: 120 men and women

Duration: 3 weeks

Dose: 300mg Blackcurrant Anthocyanin per day

Results: Significant reduction of inflammatory compounds in the blood

Institution: University of Oslo and the Ullevaal University Hospital in Norway

Publication: Paur, P. et al. (2007)

Clinical Research: (Subjects 118)

Blackcurrants Reduce Expression of Cytokines Involved in Causing Inflammation

 3.Begins in the lungs and ends in the lungs = Covid-19    

COVID-19 is the same respiratory disease as influenza, and the new viral gene has many similarities with the SARS virus, so it was named SARS-CoV-2.

Specific symptoms may start with fever, cough, no smell, and no taste and eventually develop acute pneumonia like ARDS caused by Cytokine Storm.

The Lancet Medical Journalsays that 25% of people are asymptomatic but others get infected from those infected people with no symptoms and 21% of the infected people become serious ill and need mechanical ventilation to survive from ARDS. The Lancet emphasizes that in the getting ill process of infected people there are clearly three steps:

VIRAL REPLICATION

       ↓↓

CYTOKINE STORM (IMMUNE OVERREACTION)

       ↓↓

LUNG COLLAPSE

The coronavirus itself does not mostly and directly damage the body but their own defense system of cytokinescauses their body’s immune system to overreact, resulting in bad infections in his own lungs, heart, kidneys, which may results in multiple organ failuresuch as sepsis.

The sharpest divide came at age 70. Although 4% of patients in their 60s died, more than twice that, or 8.6%, of those in their 70s did, Covid-19 kills an estimated 14.8 % of patients 80 and older.

Covid-19 is on track to kill far more people in the United States this year than the seasonal flu.

But some people don’t even get symptoms. Recent studies suggest as many as 80 percent or more of those infected are “silent carriers”, showing no or very mild symptoms. It seems children and young, healthy people are more likely to be asymptomatic.

Boost Up an Excellent Adaptive Immune Response!!

Having a strong immune response during the incubation period can prevent the infection taking hold, reduce the actual quantity of virus in the body and prevent it from getting to the lungs.

By generating an early adaptive immune response, the body seems to recognize the virus during the incubation period and fight it off.

A person also needs to be generally healthy to be able to mount an appropriate immune response to the infection.

Less ACE 2 or More ACE 2?  Important  – Healthy Modulation of ACE 2 

Elderly people and those with chronic lung disorders are more likely to develop ARDS and therefore to die if they got infected. This is currently thought to be due to these groups of people having fewer ACE2 receptors in their lungs.

This seems counter-intuitive, because the virus attaches itself to these receptors. However, ACE2 receptors have an important role in regulating the immune response, particularly in managing the degree of inflammation.

So the reduced levels of ACE2 receptors in the elderly may actually make them more at risk of a cytokine storm and severe lung disease.

The pandemic has upended life around the world, crippling the global economy and creating a “new normal” for World People Life and Economy.

ONE YEAR TO DEVELOP A VACCINES AND ANOTHER YEAR TO DISTRIBUTE COMMERCIALLY

Although German prime minister Angela Merkel said at the G-20 video conference 3/25 this year that “This pandemic is a global challenge and we will therefore also only able to overcome it globally under a joint collaboration in development and distribution” , however during the past experiences of the 2009 flu pandemic causing approximately 300,000 death all the countries agreed to develop and distribute globally, but the countries who could afford to bought up and hoarded them to ensure their countries’ populations would get satisfied with  their own vaccinated  once those new vaccines came to the markets first.

PEOPLE WITH GOOD ADPTIVE IMMUNE RESPONSE CAN SURVIVE and SATISFACTORLY WAIT FOR THE VACCINECOMPLETION!!

It has been evident that people who have good health with excellent adaptive immune responses could be able to survive from the past 2009 flu Pandemic, SARS and MERS without suffering nothing or from serious sickness because it also took a year from each break-out to develop those vaccines and spent another year to distribute in the world with massive commercialized production completed.

Please Stay Safe and Healthy For Yourself and Your Family!!

Please be advised that we haven’t tested blackcurrant anthocyanins on the cell adsorption and/or Cytokine Storm in vitro or by human. However, Blackcurrant anthocyanins contained in Vision Smart Supreme support to improve our immune system by taking it for a while from many studies done in the past 20 years.